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Lewy Body Dementia (LBD)

  • first described by Dr. Levi in 1912

  • a form of progressive dementia identified by abnormal structures in neurons called “Lewy bodies“ which are composed mainly of a protein called alpha synuclein and are distributed in the cortex and the midbrain [5]

  • the mechanism that leads to the formation of Lewy bodies is unknown

  • cerebral atrophy is present along with neurofibrillary tangles, however, minimal neuritic plaques are seen

  • LBD has a greater frequency of depressive and psychotic symptoms with a fluctuating level of consciousness and cognitive symptoms occurring within one year of the onset of Parkinsonian motor symptoms [5]

  • more information can be obtained on the Lewy Body Dementia Association website

     

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5. McKeith IG. Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia. Neurologic Clinics 2000; 18(4):865-902.

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