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Mixed Type

  • increasing evidence shows that VaD and AD often coexist in older patients and is called mixed dementia

  • cardiovascular disease (CVD) is the pathology and VaD is the disorder  and VaD with no AD pathology is relatively uncommon as shown in the figure below

    Image

  • many patients have overlap of AD and significant CVD

  • over 60% of patients diagnosed with AD also have incomplete white matter infarction on imaging [3]

  • cerebral ischemia and amyolid deposits may synergize to produce AD and vascular changes in the brain [4]

  • a great deal of research is currently being conducted to clarify these mechanisms

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3. Englund E, Person B. Correlations between histopathologic white matter changes and proton MR relaxation times in dementia. Alzheimer Dis Assoc Disord 1987; 1:156-70.

4. Gorelic PB. Risk factors for vascular dementia and Alzheimer's Disease. Stroke 2004; 35:2620-22.

All references for this section